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Is normal-tension glaucoma a risk factor for stroke?-A 10-year follow-up study
Meng-Sheng Lee1, Li-Lin Kuo1,2,3, Elise Chia-Hui Tan4,5
1Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.
Plos One
|June 20, 2017
Summary
Patients with normal-tension glaucoma (NTG) face a significantly higher risk of stroke. This study highlights NTG as a key risk factor for stroke, emphasizing the need for early preventative interventions.
Area of Science:
- Ophthalmology
- Neurology
- Epidemiology
Background:
- Normal-tension glaucoma (NTG) is an optic neuropathy.
- The association between NTG and stroke risk is not fully understood.
- Investigating this link is crucial for patient management.
Purpose of the Study:
- To determine if patients with normal-tension glaucoma (NTG) have an increased incidence of stroke.
- To assess NTG as a risk factor for subsequent stroke.
- To inform clinical practice regarding stroke prevention in NTG patients.
Main Methods:
- Population-based retrospective cohort study using Taiwan's NHIRD (2001-2010).
- Identified 1,218 NTG patients (≥20 years) and controls, excluding prior stroke history.
- Used propensity score matching and Cox regression to analyze stroke risk (Hazard Ratio).
Main Results:
- Adjusted Hazard Ratio for stroke in NTG patients was 6.34, indicating significantly higher incidence.
- Increased stroke risk observed in NTG patients across various comorbidity subgroups.
- NTG identified as a significant independent risk factor for stroke.
Conclusions:
- Normal-tension glaucoma is a significant risk factor for subsequent stroke.
- Early stroke prevention interventions are recommended for newly diagnosed NTG patients.
- Further research into shared mechanisms between NTG and stroke is warranted.
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