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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
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Long noncoding RNA and its contribution to autism spectrum disorders.
Jie Tang1,2, Yizhen Yu3, Wei Yang4,5
1The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
CNS Neuroscience & Therapeutics
|June 22, 2017
Summary
Long noncoding RNAs (lncRNAs) are crucial in gene regulation and brain development. This review explores their roles in neurodevelopmental disorders like autism spectrum disorders (ASDs).
Area of Science:
- Genomics
- Neuroscience
- Molecular Biology
Background:
- Long noncoding RNAs (lncRNAs) are increasingly recognized for their diverse roles in biological processes.
- A significant portion of the mammalian genome's transcriptional output consists of lncRNAs, yet their functions remain largely uncharacterized.
- lncRNAs are notably abundant in the human brain and implicated in neurodevelopment and associated disorders.
Purpose of the Study:
- To review the known functions of long noncoding RNAs.
- To explore the potential involvement of lncRNAs in autism spectrum disorders (ASDs).
- To examine the contribution of lncRNAs to genetic syndromes with ASD-like clinical features, such as fragile X and Rett syndromes.
Main Methods:
- Literature review of recent studies on lncRNA functions.
- Analysis of lncRNA involvement in neurodevelopment.
- Comparative review of lncRNAs in ASDs and related genetic syndromes.
Main Results:
- lncRNAs are involved in epigenetic regulation, gene expression, development, and disease.
- lncRNAs play a significant role in brain function and neurodevelopment.
- Specific lncRNAs may contribute to the pathogenesis of ASDs and similar genetic disorders.
Conclusions:
- Understanding lncRNA functions is critical due to their prevalence and roles in complex biological processes.
- lncRNAs represent a promising area for research into neurodevelopmental disorders.
- Further investigation into lncRNAs could reveal novel insights into ASDs and related conditions.
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