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Updated: Feb 28, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
[Correction of pathological conditions associated with insulin-resistant hyperglycaemia]
E Yu Solovyeva1, A N Karneev1, E A Tyutyumova1
1Pirogov Russian National Research Medical University.
Abstract:
High level of glucose in the blood in hypoxic-ischemic states is one of the main factors that complicates the degree of brain damage. An increased level of reactive oxygen species and impaired functioning of the endogenous antioxidant system are the consequences of the hyperglycemic-ischemic condition. Medical treatment is necessary to compensate for the development of cerebrovascular disorders in ischemia comorbid to diabetes mellitus. The use of antioxidants (2-ethyl-6-methyl-3-hydroxypyridine succinate) is the most therapeutically effective.
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