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[Antithrombotic treatment as primary and secondary prevention of stroke]

E I Chukanova1, A S Chukanova1, G G Nadareyshvili1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 22, 2017
PubMed

Insights

Antithrombotic drugs, like acetylsalicylic acid (ASA), are vital for preventing thrombosis, reducing heart attacks by 35% and strokes by 25%. This review highlights dipyridamole

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Antithrombotic drugs (ATD) are essential for managing and preventing thrombosis.
  • Addressing risk factors for ischemic stroke (IS) and transient ischemic attacks (TIA) is crucial.
  • Platelet-inhibiting drugs significantly reduce cardiovascular events and mortality.

Purpose of the Study:

  • To review experimental and clinical evidence on the efficacy of dipyridamole.
  • To evaluate dipyridamole's role in acute stroke treatment.
  • To assess dipyridamole's effectiveness in primary and secondary prevention of ischemic events.

Main Methods:

  • Review of experimental studies.
  • Analysis of clinical trials.
  • Examination of data on antithrombotic drug efficacy.

Main Results:

  • Drugs inhibiting platelet activation and aggregation reduce myocardial infarctions by 35% and stroke by 25%.
  • Established clinical efficacy of acetylsalicylic acid (ASA), thienopyridines, dipyridamole, and glycoprotein IIb-IIIa antagonists.
  • Evidence supports dipyridamole's utility in acute stroke and prevention.

Conclusions:

  • Dipyridamole demonstrates efficacy in treating acute stroke.
  • Dipyridamole is effective for primary and secondary prevention of ischemic events.
  • ATDs are critical in cardiovascular risk reduction.

Keywords:
antitrombotic drudscerebrovascular diseasedipyridamolendothelial dysfunctionischemic stroke

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