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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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[Pharmacotherapy and dementia].

M Yu Drobizhev1, A V Fedotova2, S V Kikta3

  • 1Sechenov First Moscow State Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 22, 2017
PubMed
Summary
This summary is machine-generated.

This review examines dementia treatments, focusing on Alzheimer's disease (AD) and vascular dementia (VD). Treatments include anticholinesterase drugs for AD and preventative therapies for VD to manage cognitive decline.

Keywords:
chronic brain ischemiadementia in Alzheimer’s diseasediscirculatory encephalopathypharmacotherapyvascular dementia

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Area of Science:

  • Neurology
  • Pharmacology
  • Geriatrics

Background:

  • Dementia, including Alzheimer's disease (AD) and vascular dementia (VD), poses significant challenges.
  • Current treatment strategies focus on managing symptoms and preventing disease progression.

Purpose of the Study:

  • To review and summarize current pharmacotherapy approaches for Alzheimer's disease (AD) and vascular dementia (VD).
  • To highlight key drug classes and their mechanisms in managing different dementia types.

Main Methods:

  • Literature review of existing studies on dementia pharmacotherapy.
  • Analysis of treatment guidelines and drug classifications for AD and VD.

Main Results:

  • Anticholinesterase drugs, such as donepezil, are central to AD pathogenetic pharmacotherapy by maintaining cholinergic neuron activity.
  • VD treatment emphasizes preventing new cerebral infarctions through cardiotropic medications, antiaggregants, anticoagulants, hypotensive drugs, and statins.
  • Polymodal drugs are utilized in Russia for both AD and VD, particularly in managing discirculatory encephalopathy and chronic brain ischemia.

Conclusions:

  • Pharmacotherapy for AD and VD involves distinct yet complementary strategies.
  • The choice of medication depends on the specific dementia type and its underlying pathophysiology.
  • Further research may explore the efficacy of polymodal drugs in broader dementia care.