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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Soluble LR11 associates with aortic root calcification in asymptomatic treated male patients with familial

Ranitha Vongpromek1, Sven Bos1, Gert-Jan R Ten Kate2

  • 1Department of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

Atherosclerosis
|June 23, 2017
PubMed

Insights

Soluble low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11) is linked to aortic root calcification in male patients with familial hypercholesterolemia (FH). This finding may explain how atherosclerotic lesions distribute differently in FH vasculature.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Genetics

Background:

  • Familial hypercholesterolemia (FH) patients exhibit high vascular calcification rates despite statin therapy.
  • Cardiovascular disease risk factors include circulating soluble low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11).

Purpose of the Study:

  • To investigate the association between plasma sLR11 levels and vascular calcification in asymptomatic, statin-treated heterozygous FH patients.

Main Methods:

  • 123 asymptomatic heterozygous FH patients (age 40-69) underwent CT scans for aortic root (ARC), aortic valve (AVC), and coronary artery calcification (CAC) scoring.
  • Plasma sLR11 levels were quantified using sandwich ELISA.

Main Results:

  • Positive correlation found between plasma sLR11 and ARC presence (r=0.2, p=0.03), but not AVC or CAC.
  • The sLR11-ARC association was significant in male FH patients (r=0.31, p=0.006).
  • Multivariate analysis confirmed sLR11 as an independent predictor of ARC (aOR=2.01, p=0.002).

Conclusions:

  • Plasma sLR11 is associated with aortic root calcification in male FH patients.
  • sLR11 may play a mechanistic role in the varied distribution of atherosclerotic lesions within the vasculature.
Abstract

Keywords:
Aortic rootFamilial hypercholesterolemiaPlasma sLR11Vascular calcification

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