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LR11/SorLA and its role in cardiovascular disease

Meander Kloosterman1, Ranitha Vongpromek1, Edith C H Friesema1

  • 1Department of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

International Journal of Cardiology. Heart & Vasculature
|August 9, 2026
PubMed

Insights

Low-density lipoprotein receptor 11 (LR11), also known as SorLA, is linked to cardiovascular diseases. Its shed form, sLR11, may serve as a biomarker and therapeutic target for atherosclerosis, obesity, and diabetes.

Area of Science:

  • Cardiovascular biology
  • Molecular mechanisms of disease
  • Biomarker discovery

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of global morbidity.
  • LR11 (SorLA), an LDL receptor family member, is implicated in Alzheimer's disease and increasingly linked to CVDs.
  • The circulating isoform, sLR11, is associated with atherosclerosis, obesity, and diabetes.

Purpose of the Study:

  • To review the role of LR11 and sLR11 in vascular remodeling and atherosclerosis.
  • To explore the involvement of LR11 in obesity and diabetes.
  • To discuss the potential of (s)LR11 as a biomarker and therapeutic target for CVDs.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of mechanisms linking LR11 to vascular remodeling.
  • Examination of LR11's role in metabolic diseases.

Main Results:

  • Elevated plasma sLR11 levels correlate with vascular injury and subsequent remodeling.
  • LR11 actively promotes vascular remodeling, contributing to atherosclerosis.
  • LR11's mechanisms may be involved in the pathophysiology of obesity and diabetes.

Conclusions:

  • LR11 and sLR11 play significant roles in vascular remodeling and atherosclerosis.
  • LR11 is implicated in the pathogenesis of obesity and diabetes.
  • (s)LR11 presents potential as a novel biomarker and therapeutic target for cardiovascular diseases.

Keywords:
BiomarkerPeripheral vasculatureSORL1 geneSORLAsLR11

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