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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Cell Diversity01:13

Cell Diversity

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The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
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Embryonic Connective Tissues01:20

Embryonic Connective Tissues

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During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Related Experiment Video

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Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
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Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth.

Jan Krivanek1, Igor Adameyko1,2, Kaj Fried3

  • 1Department of Molecular Neurosciences, Center for Brain Research, Medical University ViennaVienna, Austria.

Frontiers in Physiology
|June 23, 2017
PubMed
Summary

Teeth are complex organs formed by diverse interacting cell types, not just enamel- and dentin-producing cells. Understanding tooth cell heterogeneity is crucial for dental research and development.

Keywords:
ameloblastcell heterogeneitydental developmentdental pulpodontoblastodontogenesisstem cellstooth

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Area of Science:

  • * Developmental biology
  • * Cell biology
  • * Oral biology

Background:

  • * Organs are integrated units of multiple cell types.
  • * Teeth, essential for mastication, are complex organs with diverse cellular components.
  • * Epithelial and mesenchymal cells form the primary framework, producing enamel and dentin respectively.

Purpose of the Study:

  • * To outline the heterogeneity of cell types within teeth.
  • * To provide a life history of major tooth cell populations.
  • * To discuss evolutionary aspects of dental cell diversity and integration.

Main Methods:

  • * Review of existing literature on tooth development and cell biology.
  • * Utilizing the mouse model system for studying cell lineages and heterogeneity.
  • * Analysis of dental stem cells and tooth patterning during development.

Main Results:

  • * Teeth comprise numerous interacting cell types beyond ameloblasts and odontoblasts.
  • * Pulp cells, immune cells, vascular system, innervation, and dental follicle cells are integral to tooth function.
  • * The mouse model is vital for understanding tooth cell lineages, heterogeneity, and development.

Conclusions:

  • * Tooth formation and function involve complex interactions among diverse cell types.
  • * Understanding cellular heterogeneity is key to comprehending dental organogenesis and evolution.
  • * Further research into dental cell diversity can inform regenerative dentistry and evolutionary studies.