High-resolution ³¹ P echo-planar spectroscopic imaging in vivo at 7T

Conventional ³¹ P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of ³¹ P echo-planar spectroscopic imaging (EPSI) in vivo at 7T.

A 3D ³¹ P EPSI sequence with trapezoidal-shaped gradient pulses was implemented on a 7T MR scanner. To increase spectral width with reduced demand on gradient performance, a multishot approach was chosen. Acquisition weighting and ³¹ P-{¹ H} double resonance for nuclear Overhauser signal enhancement were applied to increase sensitivity.

3D ³¹ P-{¹ H} EPSI data from model solution and from human calf muscle and brain were obtained from voxels with effective sizes of 4.1 to 16.2 cm³ in measurement times of approximately 10 min. Individual spectra showed well-resolved resonances of endogenous ³¹ P-metabolites without artifacts. Volumetric high-resolution ³¹ P-metabolite maps in vivo showed metabolic heterogeneity of different tissues.

In vivo ³¹ P EPSI at 7T yields high-quality metabolic images. The proposed multishot EPSI technique reduces the measurement times for acquisition of volumetric high-resolution maps of ³¹ P-metabolites or intracellular pH in human studies. Magn Reson Med 79:1251-1259, 2018. © 2017 International Society for Magnetic Resonance in Medicine.