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Updated: Feb 27, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Bioinspired Microfibers with Embedded Perfusable Helical Channels.

Peidi Xu1, Ruoxiao Xie1, Yupeng Liu1

  • 1Key Laboratory of Chemical Biology (Ministry of Education), Beijing Key Laboratory of Microanalytical Methods & Instrumentation, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Advanced Materials (Deerfield Beach, Fla.)
|June 23, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed a new microfluidic method to create complex helical microchannels within microfibers. This technique allows precise control over channel geometry for advanced material applications.

Keywords:
helical channelsmicrofibersmicrofluidicsperfusable vesselstissue engineering

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Area of Science:

  • Materials Science
  • Microfluidics
  • Biomimetics

Background:

  • Microchannel materials are gaining interest for their perfusability and biomimetic properties.
  • Fabricating microfibers with complex micro- or nanoscale channels presents significant challenges.

Purpose of the Study:

  • To present a novel, scalable method for generating microfibers with embedded helical channels.
  • To demonstrate precise control over helical channel characteristics and explore complex channel designs.

Main Methods:

  • Utilized an easily fabricated coaxial microfluidic device.
  • Controlled helical channel geometry by adjusting fluid flow rate ratios.
  • Investigated the mechanism of helix formation, proposing the 'heterogenerated rope-coil' effect.

Main Results:

  • Successfully generated scalable microfibers with consecutive embedded helical channels.
  • Demonstrated accurate control over helical channel characteristics via flow rate adjustments.
  • Created microfibers with Janus and double helical channels by modifying device design.
  • Theorized the 'heterogenerated rope-coil' effect to explain helix formation.

Conclusions:

  • The novel microfluidic method enables scalable fabrication of microfibers with tunable, complex helical channels.
  • The 'heterogenerated rope-coil' effect provides a theoretical basis for understanding and controlling helical patterns.
  • These microfibers show potential for applications in biomimetic structures and perfusable/permeable vessels.