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Somatostatin and peripheral blood flow in man
Angiology
|August 1, 1985
Summary
Somatostatin (SS) significantly improved blood flow in lower limbs for both healthy and arteriopathic individuals. This physiological substance also reduced heart rate, suggesting potential as a vasoactive agent.
Area of Science:
- Endocrinology
- Vascular Physiology
- Pharmacology
Background:
- Somatostatin (SS) is a known physiological regulator of hormone secretion (GH, TSH, glucagon, insulin).
- Its potential as a vasoactive agent for modulating peripheral circulation has not been extensively studied.
Purpose of the Study:
- To evaluate somatostatin (SS) as a vasoactive agent in normal and arteriopathic subjects.
- To assess the impact of SS on peripheral blood flow and heart rate.
Main Methods:
- Intravenous administration of SS via bolus (3 minutes) and infusion (30 minutes).
- Assessment of lower limb blood flow using rheography and plethysmography.
- Measurements taken before, during, and after SS administration.
Main Results:
- Somatostatin administration led to a marked improvement in lower limb blood flow.
- A significant reduction in heart rate was observed concurrently with improved blood flow.
- Effects were noted in both healthy and subjects with arteriopathy.
Conclusions:
- Somatostatin demonstrates significant vasoactive properties, enhancing peripheral circulation.
- The observed reduction in heart rate suggests a complex physiological response to SS.
- Further investigation into the mechanisms of SS action on peripheral circulation is warranted.