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Related Experiment Video

Updated: Feb 27, 2026

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
04:29

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Published on: September 19, 2019

6.8K

An unexplored brain-gut microbiota axis in stroke.

Shu Wen Wen1, Connie H Y Wong1

  • 1a Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences , Monash University , Clayton , Victoria , Australia.

Gut Microbes
|June 23, 2017
PubMed
Summary

Stroke can lead to gut barrier dysfunction and changes in gut bacteria. This may cause bacteria to move to the lungs, causing pneumonia and increasing stroke risks.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Neurology

Background:

  • Gut microbiota research is advancing rapidly with new technologies.
  • Current research often focuses on chronic effects of microbiota manipulation.
  • Bacterial pneumonia is a significant cause of stroke-related mortality.

Purpose of the Study:

  • To investigate the unconventional hypothesis that gut microbiota contributes to post-stroke pneumonia.
  • To explore the role of anaerobic bacteria translocating from the gut to the lungs after stroke.

Main Methods:

  • Analysis of gut microbiota changes and intestinal barrier integrity post-stroke.
  • Investigating bacterial translocation from the gut to peripheral tissues, specifically the lungs.
  • Reviewing recent supporting studies on microbiota and stroke.
Keywords:
Strokebacterial translocationgut microbiotainfection

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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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Last Updated: Feb 27, 2026

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
04:29

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

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Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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Main Results:

  • Stroke was shown to disrupt the intestinal barrier.
  • Significant alterations in gut microbiota composition were observed post-stroke.
  • Translocation of specific gut bacteria to the lungs was linked to post-stroke infections.

Conclusions:

  • Gut microbiota dysbiosis and intestinal barrier breakdown following stroke can lead to bacterial translocation and pneumonia.
  • This mechanism offers a novel explanation for negative microbiological cultures in stroke-associated pneumonia.
  • Findings suggest potential new therapeutic targets for preventing stroke complications.