Spike detection using a multiresolution entropy based method

Correct interpretation of neural mechanisms depends on the accurate detection of neuronal activities, which become visible as spikes in the electrical activity of neurons. In the present work, a novel entropy based method is proposed for spike detection which employs the fact that transient spike events change the entropy level of the neural time series. In this regard, the time-dependent entropy method can be used for detecting spike times, where the entropy of a selected segment of a neural time series, using a sliding window approach, is calculated and the time of the events are highlighted by sharp peaks in the output of the time-dependent entropy method. It is shown that the length of the sliding window determines the resolution of the time series in entropy space, therefore, the calculation is performed with a different window length for obtaining a multiresolution transform. The final decision threshold for detecting spike events is applied to the point-wise product of the time dependent entropy calculations with different resolutions. The proposed detection method has been assessed using several simulated and real neural data sets. The results show that the proposed method detects spikes in their exact times while compared with other traditional methods, relatively lower false alarm rate is obtained.