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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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[Disseminated interdigitating dendritic cell sarcoma].

Ignacio M Santarelli1, Mariano Veltri1, Diego J Manzella1

  • 1Departamento de Medicina, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.

Medicina
|June 24, 2017
PubMed
Summary
This summary is machine-generated.

Interdigitating dendritic cell sarcoma is a rare cancer. This case highlights a 70-year-old woman with disseminated disease, who unfortunately passed away after one cycle of chemotherapy.

Keywords:
interdigitating cellsinterdigitating dendritic cell sarcomasarcoma

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Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignant neoplasm of dendritic cells.
  • This condition often presents with non-specific symptoms, leading to diagnostic challenges.

Observation:

  • A 70-year-old female presented with a 3-month history of abdominal pain, weight loss, and night sweats.
  • Physical examination revealed a significant abdominal mass and multiple supraclavicular adenopathies.

Findings:

  • A biopsy confirmed disseminated interdigitating dendritic cell sarcoma.
  • The patient received one cycle of the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone).

Implications:

  • The aggressive nature of disseminated IDCS poses a significant treatment challenge.
  • This case underscores the importance of early diagnosis and the limited treatment options for advanced-stage disease.