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RNA Binding Proteins and Genome Integrity

Kensei Nishida1, Yuki Kuwano2, Tatsuya Nishikawa3

  • 1Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan. knishida@tokushima-u.ac.jp.

International Journal of Molecular Sciences
|June 24, 2017
PubMed

Insights

RNA-binding proteins (RBPs) are crucial for maintaining genome integrity by participating in DNA damage response and repair. This review highlights their essential roles in preventing DNA damage and ensuring cellular survival.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Genome integrity is vital for cellular survival and is threatened by various stressors.
  • The DNA damage response network, involving DNA-binding proteins, counteracts these threats.
  • Emerging evidence implicates RNA-binding proteins (RBPs) and RNA metabolism in DNA repair processes.

Purpose of the Study:

  • To review and highlight the critical roles of RNA-binding proteins (RBPs) in maintaining genome integrity.
  • To explore the involvement of RBPs in DNA damage prevention and repair mechanisms.
  • To underscore the intricate association between RNA metabolism and genome stability.

Main Methods:

  • Literature review of recent studies on RBPs and DNA damage response.
  • Analysis of the mechanisms by which RBPs are recruited to DNA damage sites.
  • Synthesis of findings on the roles of non-coding RNAs and RNA modifications in DNA repair.

Main Results:

  • Several RBPs are recruited to DNA damage sites and directly participate in DNA repair.
  • Non-coding RNAs are involved in RNA-mediated DNA repair systems.
  • RNA modifications, like m6A methylation, may contribute to DNA damage response, particularly to UV damage.

Conclusions:

  • RNA metabolism plays a more significant role in cellular functions, including genome maintenance, than previously understood.
  • RBPs are essential players in the network that maintains genome integrity.
  • Further research into RNA-related mechanisms will deepen our understanding of genome stability.
Keywords:
DNA damage responseR-loopRNA-binding proteintelomere

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