Turning-ON Proteasomes
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Updated: Feb 27, 2026

Assaying Proteasomal Degradation in a Cell-free System in Plants
Published on: March 26, 2014
Jan Henrik Krahn1, Farnusch Kaschani1, Markus Kaiser1
1Chemical Biology, University of Duisburg-Essen, ZMB, Faculty of Biology, Universitätsstraße 2, 45117 Essen, Germany.
Abstract:
While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are much less explored. In this issue of Cell Chemical Biology, in a study from the groups of Berkers and Ovaa (Leestemaker et al., 2017), a chemical screen was used to identify a p38 MAPK inhibitor as a proteasome activator. This compound furthermore enhanced clearance of protein aggregates, thereby implicating alternative chemotherapeutic options for treating neurodegenerative diseases.
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