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Updated: Feb 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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[Headache News].

Hans-Christoph Diener, Charly Gaul, Dagny Holle-Lee

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    |June 24, 2017
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    Summary
    This summary is machine-generated.

    This review covers recent advances in headache and facial pain disorders, focusing on migraine epidemiology, pathophysiology, and new treatments like CGRP antagonists and monoclonal antibodies. It also includes updates on other headache types.

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    Area of Science:

    • Neurology
    • Pain Medicine
    • Neuroscience

    Background:

    • Headache and facial pain disorders encompass a range of conditions with significant impact.
    • Recent research has expanded understanding of migraine's epidemiology, genetics, and pathophysiology.
    • Advances in treatment strategies are continuously emerging.

    Purpose of the Study:

    • To present a comprehensive review of the latest information on head and facial pain disorders.
    • To highlight recent findings in migraine research, including epidemiology, pathophysiology, and therapeutic advancements.
    • To summarize new data on trigemino-autonomic headache, trigeminal neuralgia, and new daily persistent headache.

    Main Methods:

    • Review of recent epidemiologic studies on migraine.
    • Analysis of new insights into migraine pathophysiology, including hypothalamic and brain-stem involvement.
    • Evaluation of recent clinical studies and meta-analyses on acute and prophylactic migraine treatments, including CGRP antagonists and monoclonal antibodies.

    Main Results:

    • Epidemiologic updates include associations between migraine and patent foramen ovale, cardiovascular risks, menopausal effects, white matter lesions, and genetics.
    • Pathophysiological insights highlight the role of the hypothalamus and brain-stem.
    • New data support the efficacy and safety of CGRP antagonists (e.g., ubrogepant) and monoclonal antibodies for migraine prevention.
    • Updates on triptan use in specific migraine types and other headache disorders are discussed.

    Conclusions:

    • Significant progress has been made in understanding migraine, with promising new therapeutic options emerging.
    • CGRP-targeted therapies and monoclonal antibodies represent a major advancement in migraine management.
    • The review provides a consolidated overview of recent developments across various headache disorders, informing clinical practice and future research.