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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
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Drug-Resistant tuberculosis - primary transmission and management
Alexander C Outhred1, Philip N Britton1, Ben J Marais1
1The Children's Hospital at Westmead and the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
The Journal of Infection
|June 26, 2017
Summary
Drug-resistant tuberculosis (TB) is spreading globally, despite control efforts. Enhanced infection control and improved access to treatment are crucial, especially for vulnerable children in endemic areas.
Area of Science:
- * Infectious Diseases
- * Public Health
- * Genomics
Background:
- * The Directly Observed Treatment Short-course (DOTS) strategy has been instrumental in global tuberculosis (TB) control.
- * However, DOTS has been insufficient in preventing the emergence and spread of drug-resistant TB strains.
- * Genomic data reveal widespread transmission of drug-resistant Mycobacterium tuberculosis, indicating epidemic potential.
Purpose of the Study:
- * To review new insights into the transmission dynamics of drug-resistant TB.
- * To estimate the disease burden of drug-resistant TB in children.
- * To discuss optimal management strategies for drug-resistant TB, particularly in vulnerable populations.
Main Methods:
- * Review of genomic evidence on Mycobacterium tuberculosis transmission.
- * Analysis of disease burden in children affected by drug-resistant TB.
- * Synthesis of current knowledge on management and control strategies.
Main Results:
- * Genomic studies confirm the transmission of drug-resistant TB strains across diverse settings.
- * Young children in TB-endemic regions are identified as a particularly vulnerable group.
- * There is an urgent need for advances in TB drug and vaccine development.
Conclusions:
- * Enhanced infection control measures are essential in healthcare and congregate settings to curb TB spread.
- * Improving access to existing preventive therapies and treatments for drug-resistant TB can reduce disease burden and negative outcomes in children.
- * Integrated strategies addressing transmission, burden, and management are critical for combating drug-resistant TB.
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