Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Assessment of the Cardiovascular System III: Palpation

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Geometry-Aware Abdominal Aortic Aneurysm Digital Twin for Patient-Specific Wall Stress Mapping.

Research square·2026

Same author

Forecasting Patient-Specific Abdominal Aortic Aneurysm Geometry with Mixed-Effects Models.

Diagnostics (Basel, Switzerland)·2026

Same author

Pelvic venous disease: A frontier of possibility.

Vascular medicine (London, England)·2026

Same author

Major Adverse Limb Events and Death After Successful Endovascular Revascularization: BEST-CLI Trial.

Journal of the Society for Cardiovascular Angiography & Interventions·2026

Same author

Geometry quantification for growth assessment of abdominal aortic aneurysms under surveillance.

Scientific reports·2026

Same author

An Integrated Framework for Automated Image Segmentation and Personalized Wall Stress Estimation of Abdominal Aortic Aneurysms.

Bioengineering (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels

Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels

Published on: October 7, 2021

Characterizing tissue perfusion after lower extremity intervention using two-dimensional color-coded digital

Ann H Kim¹, Andrew J Shevitz², Katherine L Morrow²

¹Division of Vascular Surgery and Endovascular Therapy, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Journal of Vascular Surgery

|June 26, 2017

Summary

This study introduces a novel real-time imaging software for quantifying lower extremity tissue perfusion in peripheral arterial disease (PAD) patients. The two-dimensional perfusion (2DP) imaging shows promise for assessing treatment effectiveness immediately after intervention.

More Related Videos

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Published on: June 8, 2019

Related Experiment Videos

Last Updated: Feb 27, 2026

Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels

Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels

Published on: October 7, 2021

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Published on: June 8, 2019

Area of Science:

Vascular Imaging and Interventional Radiology
Medical Software and Image Analysis

Background:

Digital subtraction angiography (DSA) provides qualitative assessment of blood flow, lacking quantitative perfusion data.
Accurate, real-time tissue perfusion assessment in the lower extremities is crucial for managing peripheral arterial disease (PAD).
Current methods do not allow for immediate, quantitative evaluation of perfusion during endovascular procedures.

Purpose of the Study:

To evaluate a novel real-time imaging software for quantifying lower extremity tissue perfusion in PAD patients.
To assess the ability of two-dimensional perfusion (2DP) imaging to provide real-time perfusion parameters during angiography.
To determine if 2DP can enable immediate assessment of treatment effectiveness in PAD.

Main Methods:

Thirty-one patients with PAD underwent lower extremity angiography using a two-dimensional perfusion (2DP) imaging protocol.
Perfusion parameters including arrival time (AT), wash-in rate (WIR), time to peak (TTP), and area under the curve (AUC) were measured.
A subset of 18 patients had 2DP imaging performed before and after intervention, with constant imaging settings.

Main Results:

The 2DP imaging successfully delineated tissue perfusion parameters in the foot.
Post-intervention, significant improvements were observed: shortened AT (30.1%), decreased TTP (17.6%), increased WIR (68.8%), and increased AUC (10.5%).
A detectable improvement in signal intensity and 2D flow parameters was evident after intervention.

Conclusions:

Two-dimensional perfusion (2DP) imaging serves as a valuable adjunct to DSA, enabling real-time blood flow measurement.
Arrival time (AT) may be the most sensitive indicator of perfusion changes in the lower extremity.
Quantitative thresholds derived from 2DP imaging show potential for immediate assessment of treatment effectiveness in PAD patients.