Related Experiment Video

Updated: Feb 27, 2026

Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture
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Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture

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Emerging roles of protein disulfide isomerase in cancer

Eunyoug Lee1, Do Hee Lee1

  • 1Department of Bio and Environmental Technology, Seoul Women's University, Seoul 01797, Korea.

BMB Reports
|June 27, 2017
PubMed

Insights

Protein disulfide isomerase (PDI) enzymes are crucial for protein folding in the endoplasmic reticulum (ER). PDI

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Protein disulfide isomerase (PDI) is a key enzyme family located in the endoplasmic reticulum (ER).
  • PDI enzymes are multifunctional, involved in disulfide bond formation, redox reactions, and protein quality control.
  • PDI plays a critical role in maintaining proteostasis within the ER.

Purpose of the Study:

  • To review the properties and diverse functions of human PDI proteins.
  • To highlight recent findings on PDI's role in human diseases, particularly cancer and neurodegeneration.
  • To discuss PDI as a potential therapeutic target for cancer treatment.

Main Methods:

  • This study is a review article, synthesizing existing structural and functional data on PDI.
  • Literature search focusing on PDI's involvement in cancer proliferation, survival, and metastasis.
  • Analysis of PDI's role in neurodegenerative diseases.

Main Results:

  • PDI members are essential for ER proteostasis and impact various human disorders.
  • Evidence indicates PDI actively contributes to cancer cell proliferation, survival, and metastasis.
  • The precise molecular mechanisms of PDI in tumorigenesis and metastasis require further elucidation.

Conclusions:

  • PDI is implicated in the pathogenesis of cancer and neurodegenerative diseases.
  • PDI is emerging as a promising therapeutic target for anti-cancer drug development.
  • Further research is needed to fully understand PDI's complex roles in disease.

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