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[Aging and homeostasis. Aging of bone.]
1Center for the Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Japan.
Clinical Calcium
|June 27, 2017
Summary
Aging causes bone loss in men and women, affecting bone structure and fracture risk. Estrogen plays a key role in bone aging, even in men, alongside testosterone and cellular senescence.
Area of Science:
- Gerontology
- Endocrinology
- Orthopedics
Background:
- Bone loss and microarchitectural changes occur with aging in both sexes.
- Sex steroids, estrogen and testosterone, are crucial in bone aging.
- Diminishing estrogen in women is linked to postmenopausal osteoporosis.
Purpose of the Study:
- To explore the role of sex steroids and cellular senescence in age-related bone loss.
- To investigate the correlation between bone mineral density and sex steroid levels in men.
Main Methods:
- Review of existing literature on bone aging and sex steroids.
- Analysis of correlations between bone mineral density and circulating estrogen/testosterone levels.
- Consideration of the role of senescent osteocytes and their secretory phenotype.
Main Results:
- Estrogen levels correlate with bone mineral density in men, unexpectedly more so than testosterone.
- Senescent osteocytes and their secretory phenotype may contribute to age-related bone loss.
- Osteoporosis is viewed as an aging process influenced by genetic and environmental factors.
Conclusions:
- Estrogen is a critical factor in age-related bone loss for both men and women.
- Cellular senescence in osteocytes is a potential contributor to osteoporosis.
- Osteoporosis development is multifactorial, involving aging, genetics, and environment.
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