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Updated: Feb 27, 2026

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
Published on: January 7, 2019
[Aging and homeostasis. Aging of articular cartilage and chondrocytes.]
Takehiko Matsushita1, Toshikazu Tanaka1
1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan.
Abstract:
Articular cartilage is an important structure contributing to shock absorption and joint lubrication. Aging and trauma cause loss of function of articular cartilage, resulting in osteoarthritis(OA). Chondrocyte, the only type of the cell that resides in the articular cartilage. Recent studies have revealed that aging-associated changes in chondrocytes are important causative factors of OA. This review describes various mechanism and factors involved in aging of articular cartilage and chondrocytes.
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