Related Experiment Video
Updated: Feb 27, 2026
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
8.9K
[Aging and homeostasis. Circadian rhythms and aging.]
1Laboratory of Photobiology, Department of Ophthalmology, Keio University School of Medicine/PRESTO, JST, Tokyo, Japan.
Clinical Calcium
|June 27, 2017
Summary
The body's internal circadian clock regulates daily rhythms and is influenced by feeding and fasting cycles. Understanding this timing is key to addressing age-related changes in circadian rhythms.
Area of Science:
- Chronobiology
- Molecular Biology
- Nutritional Science
Background:
- Daily physiological and behavioral processes are governed by the internal circadian clock.
- Circadian clock gene expression oscillates rhythmically within most body cells.
- The circadian clock synchronizes with environmental cues like light and food intake.
Purpose of the Study:
- To investigate the influence of feeding and fasting cycles on circadian clock gene expression.
- To understand the interplay between the clock oscillator system and nutrient homeostasis.
- To explore the implications for age-related alterations in circadian rhythms.
Main Methods:
- Analysis of circadian clock gene expression patterns.
- Investigation of nutrient homeostasis regulators.
- Correlation of feeding-fasting cycles with circadian rhythmicity.
Main Results:
- Feeding and fasting timing significantly impacts daily rhythms of clock gene expression.
- Circadian rhythms in nutrient homeostasis are strongly affected by feeding schedules.
- The clock oscillator system plays a crucial role in mediating these effects.
Conclusions:
- The timing of food intake is critical for maintaining healthy circadian rhythms.
- Understanding feeding-fasting cycles offers insights into mitigating age-related circadian disruptions.
- This knowledge can inform strategies for adjusting aging-related changes in biological timing.
Related Concept Videos
01:26Aging
903
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
903
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
01:10Homeostatic Imbalance
39.2K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
However, sometimes these feedback loops fail,...
39.2K
01:19The Effect of Aging on Tissues
4.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
429
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
429
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
284
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
284