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Related Experiment Video

Updated: Feb 27, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Fast Chemical Exchange Saturation Transfer (CEST) Imaging with Variably-accelerated Sensitivity Encoding (vSENSE).

Yi Zhang1, Hye-Young Heo1, Dong-Hoon Lee1

  • 1Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States.

Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition
|June 27, 2017
PubMed
Summary

This study introduces variably-accelerated sensitivity encoding (vSENSE) for faster chemical exchange saturation transfer (CEST) imaging. The novel method achieved a 4-fold acceleration, significantly reducing scan times for clinical applications.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Radiology

Background:

  • Chemical Exchange Saturation Transfer (CEST) imaging offers valuable clinical applications.
  • Long acquisition times currently limit the widespread clinical adoption of CEST imaging.

Purpose of the Study:

  • To develop and validate a novel imaging method for accelerated CEST acquisitions.
  • To improve the speed of CEST imaging compared to conventional techniques.

Main Methods:

  • A new variably-accelerated sensitivity encoding (vSENSE) technique was developed.
  • vSENSE involves variable undersampling of k-space across different saturation frequencies.
  • The method was tested using phantom studies and in 8 brain tumor patients at 3T.

Main Results:

  • vSENSE achieved a 4-fold acceleration in image acquisition.
  • Conventional SENSE provided only a 2-fold acceleration.
  • Both methods were compared against a full k-space reconstruction.

Conclusions:

  • The vSENSE method significantly accelerates CEST imaging acquisition times.
  • This advancement holds promise for overcoming current limitations in clinical CEST imaging.
  • Faster CEST imaging can enhance diagnostic capabilities and patient throughput.