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Updated: Feb 27, 2026
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
Published on: December 15, 2023
Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment
Daniel Domingo-Fernández1,2, Alpha Tom Kodamullil1,2, Anandhi Iyappan1,2
1Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.
Motivation:
The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases.
Results:
We have developed a knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a 'mechanism-enrichment server' that supports the mechanistic interpretation of multiscale, multimodal clinical data.
Availability And Implementation:
NeuroMMSig is available at http://neurommsig.scai.fraunhofer.de/.
Contact:
martin.hofmann-apitius@scai.fraunhofer.de.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
