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Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases

Jose Coelho-Lima1, Ioakim Spyridopoulos2

  • 1Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom.

Experimental Gerontology
|June 28, 2017
PubMed

Insights

Ageing impacts cardiovascular health through chronic inflammation and immune system changes. Non-coding RNAs (ncRNAs) are key regulators of T cell function and may influence age-associated cardiovascular diseases.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Molecular Biology

Background:

  • Cardiovascular diseases (CVDs) are increasing with longer life expectancy.
  • Chronic inflammation and immune system alterations characterize cardiovascular ageing.
  • Molecular mechanisms of immune-mediated cardiovascular ageing are not fully understood.

Purpose of the Study:

  • To review the role of non-coding RNAs (ncRNAs) in T cell ageing.
  • To explore ncRNA regulation of T cell differentiation and function in CVDs.
  • To discuss the impact of ncRNAs on age-associated cardiovascular conditions.

Main Methods:

  • Literature review of current research on ncRNAs and T cell immunity.
  • Analysis of molecular mechanisms linking ncRNAs to cardiovascular ageing.
  • Synthesis of data on ncRNA involvement in atherosclerosis, acute coronary syndromes, and heart failure.

Main Results:

  • Non-coding RNAs (ncRNAs) are critical regulators of T cell immunity.
  • ncRNAs influence T cell differentiation, function, and the ageing process.
  • Evidence suggests ncRNAs play a role in the pathogenesis of age-associated CVDs.

Conclusions:

  • ncRNAs represent a significant area of study for understanding immune-mediated cardiovascular ageing.
  • Targeting ncRNAs may offer novel therapeutic strategies for age-associated CVDs.
  • Further research is needed to elucidate specific ncRNA functions in cardiovascular ageing and disease.

Keywords:
Cardiovascular ageingNon-coding RNAsT cell

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