Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

16
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
16
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

35
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
35
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

30
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
30
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

21
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
21
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

23
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
23
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

22
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
22

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trientine for hypertrophic cardiomyopathy: a phase 2 trial.

European heart journal·2026
Same author

Cardiac myosin-binding protein C in community-based patients with suspected heart failure.

European journal of heart failure·2026
Same author

Long-Term Outcomes in NSTEMI Patients Based on Coronary TIMI Flow State on Presentation.

Journal of clinical medicine·2026
Same author

Endotype-informed therapy and effects on illness perception and psychological health in patients with chest pain and no obstructive coronary artery disease.

European heart journal. Quality of care & clinical outcomes·2026
Same author

Targeting RUNX1 protects against diastolic dysfunction in a two-hit mouse model of heart failure with preserved ejection fraction.

Cardiovascular research·2026
Same author

Tele-Electrocardiography and Mortality: Clinical Outcomes in Digital Electrocardiography Cohort-Data from Belo Horizonte, Brazil (CODE-BH).

Global heart·2026

Related Experiment Video

Updated: Sep 11, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

8.6K

Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST-Segment-Elevation

Luke Spray1, Alasdair McIntosh2, Peter J McCartney3

  • 1Translational and Clinical Research Institute Newcastle University Newcastle Upon Tyne United Kingdom.

Journal of the American Heart Association
|August 12, 2025
PubMed
Summary

Latent cytomegalovirus infection is associated with poorer outcomes after ST-segment-elevation myocardial infarction (STEMI). Patients with STEMI and cytomegalovirus (CMV) positivity experienced impaired reperfusion and reduced heart function.

Keywords:
cardiovascular magnetic resonance imagingcytomegalovirusheart failureinflammationmyocardial infarction

More Related Videos

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.1K
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
05:48

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Published on: August 9, 2022

4.6K

Related Experiment Videos

Last Updated: Sep 11, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

8.6K
Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.1K
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
05:48

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Published on: August 9, 2022

4.6K

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Human cytomegalovirus (CMV) is a prevalent herpesvirus globally.
  • CMV infection is linked to increased cardiovascular disease risk.
  • The impact of CMV on ST-segment-elevation myocardial infarction (STEMI) outcomes remains unclear.

Purpose of the Study:

  • To investigate the association between latent CMV infection and patient outcomes following STEMI.
  • To determine if CMV positivity affects myocardial reperfusion, cardiac function, and quality of life post-STEMI.

Main Methods:

  • 354 STEMI patients from the T-TIME trial with cryopreserved samples were analyzed.
  • Cytomegalovirus (CMV) IgG antibody titers were measured in baseline samples.
  • Outcomes assessed included ST-segment resolution, left ventricular ejection fraction, and quality of life via EuroQol 5-Dimension visual analog scale.

Main Results:

  • CMV-positive patients (74.9%) were older and more likely to be non-White.
  • Less successful myocardial reperfusion (ST-segment resolution) was observed in CMV-positive individuals (38.7% vs. 48.4%, P=0.032).
  • CMV positivity was associated with lower left ventricular ejection fraction at 1 week (42.6% vs. 45.3%, P=0.006) and 3 months (47.8% vs. 49.7%, P=0.033), and poorer quality of life improvement (P<0.001).

Conclusions:

  • Latent cytomegalovirus infection is associated with impaired myocardial reperfusion after STEMI.
  • CMV positivity correlates with reduced left ventricular function and less improvement in quality of life in STEMI patients.
  • These findings suggest CMV may negatively influence recovery and long-term outcomes following STEMI.