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Updated: Feb 27, 2026

Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
[Cleft lip and palate]
A Voigt1,2, R J Radlanski3, N Sarioglu4
1Arbeitsbereich Lippen‑, Kiefer‑, Gaumen-Spalten, Klinik für Mund‑, Kiefer‑, Gesichts-Chirurgie, Charité - Campus Virchow, Augustenburger Platz 1, 13353, Berlin, Deutschland. alexander.voigt@charite.de.
Background:
Cleft lip and palate (CLP) represents a group of malformations of unknown etiology but similar phenotypes. This implies consequences for the diagnostics, therapy, prevention, prognosis and risk estimation.
Objective:
Definition of CLP subtypes and the embryonic development, clarification of correlations and differences between entities using epidemiological data, overview of the present state of genetic analyses, correlation to syndromes, sequences and associations and resulting consequences for clinical practice.
Material And Methods:
Update on embryological development of the face, summary of epidemiological and genetic studies and considerations on pedopathological and forensic aspects.
Results:
Syndromic and non-syndromic CLP exhibit different and highly variable etiologies, therapeutic needs and prognosis. A thorough understanding is mandatory to distinguish between the different subgroups. In addition to specific aspects of CLP for the pediatric (forensic) pathologist this article provides an overall view of the topic which aims to help understand these malformations.
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