Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Orthogonal nanopores cross-validation for multiplex single-molecule profiling.

Chemical science·2026
Same author

Cold survival in aphids: linking species-specific metabolic responses to cold tolerance.

Journal of insect physiology·2026
Same author

A Dynamic Contour Evolution Algorithm for Cell Segmentation and Synaptic Tracking under Occlusion.

Chemical & biomedical imaging·2026
Same author

Photoresponsive DNA steganography for secure information transmission by nanopore.

National science review·2026
Same author

<i>Operando</i> Nanoscale Measurements of Electrochemical Interfaces: Emerging Frontiers of Scanning Electrochemical Cell Microscopy.

Analytical chemistry·2026
Same author

Nanopore Fingerprinting of Neurodegenerative Proteins and Phosphoproteins within a Minute.

JACS Au·2026

Related Experiment Video

Updated: Feb 27, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

8.1K

Wireless Bipolar Nanopore Electrode for Single Small Molecule Detection.

Rui Gao1, Yi-Lun Ying1, Yong-Xu Hu1

  • 1Key Laboratory for Advanced Materials & School of Chemistry and Molecular Engineering, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.

Analytical Chemistry
|June 28, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel metal-coated wireless nanopore electrode (WNE) for ultrasensitive, label-free detection of small molecules and ions. This new nanoelectrode technology enables single-molecule/ion analysis, overcoming limitations of existing nanopore methods.

More Related Videos

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
12:20

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

Published on: July 22, 2013

18.8K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K

Related Experiment Videos

Last Updated: Feb 27, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

8.1K
Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
12:20

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

Published on: July 22, 2013

18.8K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K

Area of Science:

  • Nanotechnology
  • Electrochemistry
  • Analytical Chemistry

Background:

  • Solid-state nanopore techniques are promising for single molecule detection.
  • Fabricating nanopores <2 nm for small molecule detection remains challenging.
  • Existing label-free nanopore methods struggle with small analytes.

Purpose of the Study:

  • To propose a novel metal-coated wireless nanopore electrode (WNE) for small molecule and ion detection.
  • To develop an accessible method for single molecule/ion analysis.
  • To demonstrate WNE's capability in detecting the smallest molecule (H2) and ions.

Main Methods:

  • Fabrication of a silver-coated WNE.
  • Detection of H2 molecules and Ag+ ions via enhanced ionic signatures.
  • Finite element simulation to understand H2 generation at the WNE orifice.
  • Detection of Hg2+ using frequency monitoring of spike signals.

Main Results:

  • The WNE successfully detected single H2 molecules and Ag+ ions.
  • Distinguished as few as 14 H2 molecules and 28 Ag+ ions from single spike signals.
  • Demonstrated detection of Hg2+ from 100 pM to 100 nM.
  • Finite element simulation confirmed H2 generation enhances ionic current.

Conclusions:

  • The novel WNE offers a new label-free, ultrasensitive detection mechanism.
  • This technology is suitable for analyzing various small molecules and ions.
  • The WNE is particularly effective for detecting redox analytes at the single molecule/ion level.