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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Murine Model of Allergen Induced Asthma
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Age is associated with asthma phenotypes.

Eduardo V Ponte1, Aline Lima2, Paula C A Almeida2

  • 1Internal Medicine, Jundiaí Medical School, São Paulo, Brazil.

Respirology (Carlton, Vic.)
|June 28, 2017
PubMed
Summary
This summary is machine-generated.

Older adults with asthma are less likely to have atopic or eosinophilic types. They are more prone to severe asthma and irreversible airway obstruction, highlighting age-related differences in asthma.

Keywords:
allergyasthmaeosinophilslung function test

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Area of Science:

  • Respiratory Medicine
  • Clinical Immunology
  • Epidemiology

Background:

  • Asthma prevalence increases in aging populations.
  • Asthma treatment is increasingly guided by distinct phenotypes.
  • Understanding age-related asthma phenotypes is crucial for effective management.

Purpose of the Study:

  • To investigate the association between age and specific asthma phenotypes.
  • To determine if older individuals exhibit different asthma characteristics compared to younger ones.

Main Methods:

  • Cross-sectional study of 868 asthma patients.
  • Evaluated spirometry, skin prick tests, Asthma Control Questionnaire, and blood markers.
  • Utilized binary logistic regression to analyze age-related phenotype associations.

Main Results:

  • Older subjects (≥41 years) showed significantly higher odds of irreversible airway obstruction (ORs 1.83-3.45) and severe asthma (ORs 3.23-4.55).
  • Conversely, older individuals had lower odds of atopic (ORs 0.56-0.47) and eosinophilic asthma phenotypes (ORs 0.63-0.39).

Conclusions:

  • Age is significantly associated with specific asthma phenotypes.
  • Older adults with asthma are more likely to have severe, non-atopic, non-eosinophilic disease with irreversible airflow limitation.