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ELECTROPHYSIOLOGICAL CHARACTERIZATION OF MACULAR TELANGIECTASIA TYPE 2 AND STRUCTURE-FUNCTION CORRELATION
Mali Okada1, Anthony G Robson1,2, Catherine A Egan1,2
1Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom.
Retina (Philadelphia, Pa.)
|June 28, 2017
Summary
Electrophysiological testing in Macular Telangiectasia Type 2 reveals localized central retinal dysfunction. Ellipsoid zone damage on OCT imaging correlates with reduced multifocal electroretinography responses.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Imaging
Background:
- Macular telangiectasia Type 2 (MT2) is a degenerative retinal disease.
- Understanding its functional deficits is crucial for patient management.
Purpose of the Study:
- To investigate the electrophysiological characteristics of MT2.
- To correlate these findings with structural damage observed via optical coherence tomography (OCT).
Main Methods:
- Utilized electroretinography (ERG) including full-field (ffERG), pattern (PERG), and multifocal (mfERG) tests.
- Assessed 42 eyes from 21 MT2 patients.
- Employed regression modeling to link OCT-measured ellipsoid zone (EZ) break size with mfERG responses.
Main Results:
- ffERG and electrooculography were normal; PERG showed reduced P50 amplitude in 14% of eyes.
- mfERG revealed reduced central/paracentral responses in 73% of eyes.
- Significant correlation found between EZ break size and mfERG P1 amplitude and P1:N1 ratio.
Conclusions:
- Electrophysiological findings indicate localized central retinal dysfunction in MT2.
- EZ break size directly correlates with the severity of mfERG reduction.
- Reduced mfERG P1:N1 ratio suggests inner retinal dysfunction consistent with structural data.
