Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.7K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.7K
Antibiotic Selection00:57

Antibiotic Selection

61.0K
Overview
61.0K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

1.4K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.4K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.2K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.2K
Estimation of k and VD of Aminoglycosides01:20

Estimation of k and VD of Aminoglycosides

286
Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
286

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Staphylococcus aureus</i> transcriptomics and single-cell sequencing approaches.

Infection and immunity·2025
Same author

Evaluation of capsule polysaccharide (CPS)-specific antibodies for broad recognition of prominent multidrug-resistant <i>Klebsiella pneumoniae</i>.

Microbiology spectrum·2025
Same author

<i>Staphylococcus aureus</i> SaeR/S-regulated factors overcome human complement-mediated inhibition of aggregation to evade neutrophil killing.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.

Emerging infectious diseases·2025
Same author

Insights into the molecular basis of reduced vancomycin susceptibility among three prominent <i>Staphylococcus aureus</i> clonal complexes.

Microbiology spectrum·2024
Same author

Interaction of multidrug-resistant hypervirulent <i>Klebsiella pneumoniae</i> with components of human innate host defense.

mBio·2023
Same journal

Chrysoeriol-Mediated Neuroprotection in Parkinson's Disease in Mice: Targeting Apoptosis, α-Synuclein Accumulation, and Functional Recovery.

The Yale journal of biology and medicine·2026
Same journal

Musicality is Preserved in Neurodegeneration.

The Yale journal of biology and medicine·2026
Same journal

Burden of Neurological Disorders in Resource-Limited Settings: Lessons from Pakistan for Global Neurology.

The Yale journal of biology and medicine·2026
Same journal

Comparative Analysis of Prenatal Stress Models: Placental and Neurodevelopmental Outcomes in Mice.

The Yale journal of biology and medicine·2026
Same journal

Computational Investigation of Flavonoid-Associated Molecular Pathways in Astrogliosis Modulation.

The Yale journal of biology and medicine·2026
Same journal

Regulation and Interaction Among SOCS1 and SOCS3 by MicroRNAs in Multiple Sclerosis: A Review and <i>In Silico</i> Analysis.

The Yale journal of biology and medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 27, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.2K

Vancomycin Resistance in Staphylococcus aureus
.

Will A McGuinness1, Natalia Malachowa1, Frank R DeLeo1

  • 1Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT.

The Yale Journal of Biology and Medicine
|June 29, 2017
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus aureus (MRSA) poses a global health threat. Understanding vancomycin resistance mechanisms in MRSA, including vancomycin-intermediate resistant S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA), is crucial for effective treatment.

Keywords:
Staphylococcus aureusVISAVRSAantibiotic resistancevancomycin

More Related Videos

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

17.4K
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

9.5K

Related Experiment Videos

Last Updated: Feb 27, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.2K
Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

17.4K
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

9.5K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), is a significant global health concern.
  • Vancomycin is a critical antibiotic for treating severe MRSA infections.
  • The emergence of vancomycin resistance in S. aureus, including vancomycin-intermediate resistant S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA), complicates treatment strategies.

Purpose of the Study:

  • To review the progress in understanding the acquisition of antibiotic resistance in Staphylococcus aureus.
  • To emphasize the molecular mechanisms underlying vancomycin resistance in S. aureus.
  • To highlight the clinical implications of VISA and VRSA.

Main Methods:

  • Literature review of studies on Staphylococcus aureus antibiotic resistance.
  • Analysis of molecular mechanisms conferring vancomycin resistance.
  • Examination of clinical data related to VISA and VRSA infections.

Main Results:

  • VISA strains, characterized by intermediate vancomycin resistance, involve polygenic mutations affecting cell envelope biosynthesis.
  • VRSA strains exhibit complete vancomycin resistance due to the plasmid-borne vanA gene operon.
  • While VRSA infections are rare, VISA infections are more prevalent and associated with treatment failures and poor outcomes.

Conclusions:

  • The molecular basis of vancomycin resistance in S. aureus is complex and multifactorial.
  • Further research into VISA mechanisms is needed due to their clinical impact.
  • Effective strategies against MRSA require a deep understanding of evolving resistance patterns.