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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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IL-25 in allergic inflammation.

Miao Xu1, Chen Dong1

  • 1Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China.

Immunological Reviews
|June 29, 2017
PubMed
Summary
This summary is machine-generated.

Interleukin-25 (IL-25) is a cytokine that drives type 2 immunity and is implicated in allergic diseases, inflammatory bowel disease, and cancer. Further understanding IL-25 is key to developing new therapies for inflammatory conditions.

Keywords:
IL-25IL-25-mediated diseasesallergic diseasescell sourcecell targetcytokines

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Interleukin-25 (IL-25), also known as IL-17E, is a cytokine primarily produced by epithelial and innate immune cells.
  • IL-25 binds to the IL-17RB/IL-17RA receptor complex, initiating signaling pathways crucial for type 2 immunity.

Purpose of the Study:

  • To review the current literature on IL-25.
  • To discuss the known functions and potential therapeutic applications of IL-25.
  • To identify unresolved questions regarding IL-25's role in disease.

Main Methods:

  • Literature review of studies on IL-25.
  • Analysis of IL-25's role in various disease models.
  • Discussion of IL-25 signaling pathways and receptor interactions.

Main Results:

  • IL-25 is established in allergic diseases like asthma and is increasingly recognized in inflammatory bowel disease and cancer.
  • IL-25 signaling is critical for initiating, propagating, and sustaining type 2 immune responses.
  • The review highlights the broad implications of IL-25 beyond allergic conditions.

Conclusions:

  • IL-25 plays a significant role in type 2 immunity and various inflammatory diseases.
  • Targeting IL-25 presents a promising therapeutic strategy for inflammatory conditions.
  • Further research is needed to fully elucidate IL-25's mechanisms and therapeutic potential.