Related Experiment Video
Updated: Feb 27, 2026
07:50
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
16.6K
[Good's syndrome. Report of case]
Diana Andrea Herrera-Sánchez1, José Israel León-Pedroza, María Eugenia Vargas-Camaño
1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de México. dianaaherrera@outlook.com.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 29, 2017
Summary
Good's syndrome, a rare condition linking thymoma and immunodeficiency, presents with recurrent infections and low B cells. Early suspicion as a paraneoplastic manifestation of thymoma is crucial for diagnosis and management.
Area of Science:
- Immunology
- Oncology
- Endocrinology
Background:
- Good's syndrome is characterized by the co-occurrence of thymoma and primary immunodeficiency.
- Clinical manifestations include recurrent sinopulmonary infections and symptoms related to thymoma compression.
- Key laboratory findings include B-lymphocytopenia, hypogammaglobulinemia, inverted CD4/CD8 ratio, and impaired lymphocyte proliferation.
Observation:
- A 49-year-old female presented with edema, vomiting, dysphagia, diarrhea, and weight loss.
- Diagnostic workup revealed a B1 thymoma, bilateral pleural effusion, and mediastinal widening.
- Laboratory results showed hypogammaglobulinemia and a decreased CD19+ B cell count (77 cells/µL).
Findings:
- The patient was diagnosed with Good's syndrome based on thymoma and immunodeficiency.
- Treatment with intravenous immunoglobulin (IVIG) replacement therapy at 1 g/kg led to clinical improvement.
- Despite treatment, the patient unfortunately died four months later due to cardiac complications.
Implications:
- Good's syndrome underscores the importance of recognizing immunodeficiency as a paraneoplastic syndrome of thymoma.
- Prompt diagnosis and management with IVIG can improve clinical outcomes in patients with Good's syndrome.
- Further research is needed to understand the long-term prognosis and optimal treatment strategies for this rare condition.
