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Related Experiment Video

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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

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Published on: August 25, 2017

Immune checkpoints in chronic obstructive pulmonary disease.

Tom M A Wilkinson¹

¹Dept of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK T.wilkinson@soton.ac.uk.

European Respiratory Review : an Official Journal of the European Respiratory Society

|June 30, 2017

Summary

Immune checkpoints regulate T-cell function, preventing damage but causing exhaustion in chronic conditions. Understanding this mechanism offers potential therapeutic targets for diseases like COPD, similar to cancer treatments.

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Area of Science:

Immunology
Cellular Biology
Pulmonary Medicine

Background:

Cell-mediated immunity and T-cell function are crucial for fighting infections and cancer.
Immune checkpoints regulate T-cell activity to prevent self-damage, but prolonged signaling can lead to T-cell exhaustion.
Reversing T-cell exhaustion has revolutionized cancer therapy.

Purpose of the Study:

To investigate the role and dysregulation of immune checkpoints in chronic obstructive pulmonary disease (COPD).
To explore the potential for therapeutic strategies targeting immune checkpoints in COPD.

Main Methods:

Analysis of T-cell expression of programmed death-1 (PD-1) in COPD lungs.
Assessment of T-cell cytotoxic function in diseased lung tissue.
Examination of programmed death-ligand 1 (PDL1) expression on alveolar macrophages.

Main Results:

T-cells in COPD lungs express PD-1 and exhibit reduced cytotoxic function.
PDL1 expression is downregulated on alveolar macrophages in COPD.
These complex immune alterations may contribute to inflammation and lung damage in COPD exacerbations.

Conclusions:

Immune checkpoint dysregulation is implicated in COPD pathogenesis.
Further research is needed to understand these immune mechanisms in COPD.
Therapeutic approaches targeting immune checkpoints, successful in cancer, require careful consideration for COPD.