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Edge Artifacts in Point Spread Function-based PET Reconstruction in Relation to Object Size and Reconstruction

Yuji Tsutsui1, Shinichi Awamoto1, Kazuhiko Himuro1

  • 1Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan.

Asia Oceania Journal of Nuclear Medicine & Biology
|June 30, 2017
PubMed
Summary

Point spread function (PSF) reconstruction in positron emission tomography (PET) can create edge artifacts. These artifacts are influenced by factors like pixel size, filter settings, and object dimensions, impacting image accuracy.

Keywords:
Edge artifactPETPoint-spread function

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Image Reconstruction

Background:

  • Positron Emission Tomography (PET) is crucial for medical diagnostics.
  • Image reconstruction algorithms aim to improve image quality and accuracy.
  • Point Spread Function (PSF) correction is a technique used in PET reconstruction.

Purpose of the Study:

  • To evaluate edge artifacts in PSF-based PET image reconstruction.
  • To assess the impact of phantom diameter and reconstruction parameters on these artifacts.

Main Methods:

  • PET data acquired using a cone-shaped phantom with 18F.
  • Images reconstructed with baseline Ordered Subsets Expectation Maximization (OSEM) and OSEM with PSF correction.
  • Varied reconstruction parameters: pixel size, iterations, subsets, and Gaussian filter FWHM.

Main Results:

  • OSEM with PSF showed edge artifacts (dense edge/center spot) not present in baseline OSEM.
  • Artifacts were more prominent with smaller pixel sizes, smaller Gaussian filter FWHM, and higher iterations.
  • Recovery coefficients (RCmax) were significantly higher (140%) with OSEM with PSF compared to OSEM (60%) for small phantoms.

Conclusions:

  • PSF-based reconstruction introduces edge artifacts in PET imaging.
  • The severity of these artifacts is dependent on reconstruction parameters and object size.
  • Careful selection of parameters is necessary to mitigate artifacts in PSF-corrected PET images.