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Actinic keratosis modelling in mice: A translational study
Arnaud Pillon1, Bruno Gomes1, Isabelle Vandenberghe1
1Pierre Fabre Research Institute, Research & Development Center, Toulouse, France.
Plos One
|June 30, 2017
Summary
This study validates a UV-B-induced mouse model for actinic keratosis (AK) and squamous cell carcinoma (SCC) development. The model accurately predicts therapeutic treatments for early and advanced skin lesions.
Area of Science:
- Dermatology
- Preclinical Research
- Cancer Biology
Background:
- Actinic keratoses (AK) are pre-malignant skin lesions progressing to squamous cell carcinoma (SCC).
- Current AK treatments require efficacy improvement.
- UV-B-induced mouse models are used for preclinical AK/SCC studies.
Purpose of the Study:
- To compare human and UV-B-induced mouse AK lesion development.
- To optimize photographic assessment of mouse AK lesions.
- To validate a mouse model for predicting therapeutic efficacy.
Main Methods:
- Histological and immunohistochemical analysis of human and mouse AK lesions.
- Assessment of mouse lesions using digital dermoscopy.
- Optimization of digital dermoscopy for reproducible imaging.
Main Results:
- Mouse AK models show histological and phenotypic similarities to human lesions.
- Differences in keratinocyte disorganization and acanthosis were noted.
- Optimized digital dermoscopy enables reliable assessment and selection of experimental conditions.
Conclusions:
- The UV-B-induced mouse model is relevant for studying AK and SCC.
- This model can predict novel therapeutic treatments for early and advanced skin lesions.
- Optimized imaging enhances the model's utility in preclinical research.
