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E3 ubiquitin ligase, RNF139, inhibits the progression of tongue cancer

Lina Wang1,2, Wei Yin3, Chun Shi2

  • 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu road, Wuhan, 430079, China.

BMC Cancer
|July 1, 2017
PubMed
Abstract

Insights

RING finger protein 139 (RNF139) regulates tongue cancer progression. Low RNF139 expression correlates with increased cell viability, invasion, and tumorigenicity, suggesting RNF139 as a potential therapeutic target for oral cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Tongue cancer remains a significant global health concern.
  • The ubiquitin system plays a crucial role in tumor modulation.
  • Identifying oral cancer-related E3 ubiquitin ligases is essential for understanding cancer development.

Purpose of the Study:

  • To investigate the role of RING finger protein 139 (RNF139) in tongue cancer.
  • To determine if RNF139 regulates the biological behavior of tongue cancer cells.

Main Methods:

  • Cell viability assessed using MTT assays.
  • Invasion potential evaluated via transwell assays.
  • RNF139 expression analyzed in patient tissues using immunoblotting.
  • Tumorigenicity studied in a mouse xenograft model.

Main Results:

  • RNF139 overexpression inhibited tongue cancer cell viability and colony formation.
  • RNF139 knockdown enhanced cell invasion and AKT signaling pathway activation.
  • Human tongue cancer tissues exhibited low RNF139 expression.
  • RNF139 knockdown promoted tumor growth in vivo.

Conclusions:

  • RNF139 plays a critical role in regulating tongue cancer progression.
  • RNF139 acts as a tumor suppressor in tongue cancer.
  • RNF139 may represent a novel therapeutic target for oral cancer treatment.
Keywords:
Cell viabilityInvasionRNF139SCC25 cellsTongue cancer

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