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Updated: Feb 27, 2026
Mesoscopic Optical Imaging of Whole Mouse Heart
Published on: October 14, 2021
Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization
1Department of Bioengineering, University of Missouri, Columbia, MO 65211, USA.
Abstract:
We investigated the heart structural remodeling in the mdx4cv mouse model of Duchenne cardiomyopathy using optical polarization tractography. Whole heart tractography was obtained in freshly dissected hearts from six mdx4cv mice. Six hearts from C57BL/6J mice were also imaged as the normal control. The mdx4cv hearts were significantly larger than the control hearts and had significantly higher between-subject variations in myofiber organization. While both strains showed classic cross-helical fiber organization in the left ventricle, the rate of the myocardial fiber orientation change across the heart wall was significantly altered in the right ventricle of the mdx4cv heart.
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