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Related Experiment Video

Updated: Feb 27, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

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Dermoscopy guided dark-field multi-functional optical coherence tomography.

Soonjae Kwon^1,2, Yeoreum Yoon^1,2, Bumju Kim³

¹Department of Mechanical Engineering, Pohang University of Science and Technology, San 31, Hyoja-dong, Nam-gu, Pohang, Gyeongbuk 790-784, South Korea.

Biomedical Optics Express

|July 1, 2017

Summary

This summary is machine-generated.

Dermoscopy guided multi-functional optical coherence tomography (MF-OCT) enhances skin lesion analysis by combining superficial imaging with depth-resolved structural, birefringent, and vascular data. This integrated approach improves evaluation and treatment monitoring for skin conditions.

Keywords:

(130.5440) Polarization-selective devices (170.0170) Medical optics and biotechnology (170.1870) Dermatology (170.4500) Optical coherence tomography

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Area of Science:

Biomedical Optics
Dermatology
Medical Imaging

Background:

Dermoscopy offers superficial skin imaging but lacks depth information.
Existing methods struggle to provide comprehensive 3D visualization of skin lesions.

Purpose of the Study:

To develop and validate a novel dermoscopy-guided multi-functional optical coherence tomography (MF-OCT) system.
To integrate high-contrast superficial imaging with depth-resolved skin analysis.

Main Methods:

Combined dermoscopy with MF-OCT using a dichroic mirror.
Adapted dark-field configuration for MF-OCT to minimize specular reflection.
Applied the integrated system to human skin lesions (scars, port-wine stains) and normal skin.

Main Results:

The dermoscopy-guided MF-OCT system successfully provided simultaneous high-contrast superficial and depth-resolved information.
Detailed structural, birefringent, and vascular features of scars and port-wine stains were elucidated.
Demonstrated the system's capability in characterizing various skin conditions.

Conclusions:

Dermoscopy-guided MF-OCT overcomes the depth-resolution limitations of traditional dermoscopy.
This integrated imaging modality shows significant potential for clinical evaluation and treatment monitoring of skin lesions.
The system offers a comprehensive approach to skin diagnostics.