Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Reflectance-based projection-resolved optical coherence tomography angiography [Invited].

Jie Wang¹, Miao Zhang¹, Thomas S Hwang¹

¹Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Biomedical Optics Express

|July 1, 2017

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies.

Translational vision science & technology·2024

Same author

Quantitative Evaluation of Type 1 and Type 2 Choroidal Neovascularization Components Under Treatment With Projection-Resolved OCT Angiography.

Investigative ophthalmology & visual science·2024

Same author

Optical Assessment of Photoreceptor Function Over the Macula.

Translational vision science & technology·2024

Same author

Correction: Long range inter-chromosomal interaction of Oct4 distal enhancer loci regulates ESCs pluripotency.

Cell death discovery·2024

Same author

The ecology of giant kelp colonization and its implications for kelp forest restoration.

Journal of phycology·2024

Same author

Non-mydriatic ultra-widefield diffraction-limited retinal imaging.

Optics letters·2024

A new reflectance-based projection-resolved (rbPR) Optical Coherence Tomography Angiography (OCTA) method significantly improves visualization of deep retinal and choroidal vasculature by reducing projection artifacts. This technique enhances vascular integrity and detail in both healthy and diseased eyes.

Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Optical coherence tomography angiography (OCTA) suffers from projection artifacts, obscuring deeper vascular layers.
Existing projection-resolved (PR) OCTA improves depth resolution but compromises vascular integrity in deeper plexuses.

Purpose of the Study:

To introduce a novel reflectance-based projection-resolved (rbPR) OCTA algorithm.
To enhance 3D OCTA by improving flow signal and suppressing projection artifacts using OCT reflectance.

Main Methods:

Developed a novel reflectance-based projection-resolved (rbPR) OCTA algorithm.
Quantitatively assessed vascular connectivity and plexus discrimination in healthy eyes.
Qualitatively evaluated artifact removal and vascular integrity in age-related macular degeneration and diabetic retinopathy models.

Keywords:

(100.0100) Image processing (100.2960) Image analysis (110.4500) Optical coherence tomography (170.4470) Ophthalmology

More Related Videos

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Related Experiment Videos

Last Updated: Feb 27, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Main Results:

rbPR OCTA significantly improved vascular connectivity and discrimination of deeper plexuses in healthy eyes compared to PR-OCTA.
rbPR OCTA more effectively removed flow projection artifacts from the outer retinal slab in age-related macular degeneration.
Vascular integrity of intermediate and deep capillary plexuses was preserved in diabetic retinopathy using rbPR OCTA, with improved choriocapillaris resolution.

Conclusions:

The novel rbPR OCTA algorithm effectively suppresses projection artifacts while preserving and enhancing vascular integrity in deeper retinal and choroidal layers.
rbPR OCTA offers superior performance for visualizing microvasculature in various ocular conditions, achieving details comparable to scanning electron microscopy.