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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Biological Samples with Optical Microscopy01:18

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
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Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

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Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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Related Experiment Video

Updated: Feb 27, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

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Computational optical coherence tomography [Invited].

Yuan-Zhi Liu1,2, Fredrick A South1,2, Yang Xu1,2

  • 1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USA.

Biomedical Optics Express
|July 1, 2017
PubMed
Summary
This summary is machine-generated.

This review explores computational imaging techniques for overcoming limitations in high-speed, high-resolution optical coherence tomography (OCT). It highlights advancements in managing dispersion, resolution trade-offs, and optical aberrations for improved biomedical imaging.

Keywords:
(100.3175) Interferometric imaging(100.3190) Inverse problems(110.1085) Adaptive imaging(110.1758) Computational imaging(110.4500) Optical coherence tomography

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Area of Science:

  • Biomedical imaging
  • Optical physics
  • Computational imaging

Background:

  • Optical coherence tomography (OCT) is a vital biomedical imaging technique.
  • Key challenges in OCT include dispersion, resolution trade-offs, and optical aberrations.
  • Existing limitations hinder high-speed, high-resolution, volumetric OCT imaging.

Purpose of the Study:

  • To review physics-based computational imaging techniques for OCT.
  • To present a general mathematical framework for these techniques.
  • To summarize historical progress and state-of-the-art achievements in OCT computational imaging.

Main Methods:

  • Review of physics-based computational imaging approaches.
  • Mathematical framework for analyzing OCT limitations.
  • Summary of historical development and current advancements.

Main Results:

  • Computational imaging offers solutions to dispersion and aberration challenges in OCT.
  • Techniques enable improved transverse resolution and depth-of-field management.
  • State-of-the-art achievements demonstrate enhanced OCT performance.

Conclusions:

  • Computational imaging is crucial for advancing OCT capabilities.
  • Further research is needed to address present challenges in OCT.
  • These techniques hold significant potential for future biomedical applications.