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Updated: Feb 27, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Intravascular optical coherence tomography [Invited]
Brett E Bouma1,2, Martin Villiger1, Kenichiro Otsuka1
1Harvard Medical School and Massachusetts General Hospital, Boston, MA 02171, USA.
Abstract:
Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, high-performance commercial imaging systems, the key studies that laid the groundwork for image interpretation, and the clinical research that traces intravascular optical coherence tomography (OCT) from early human pilot studies to current clinical trials.
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