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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Doppler Optical Coherence Tomography of Retinal Circulation
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Intravascular optical coherence tomography [Invited].

Brett E Bouma1,2, Martin Villiger1, Kenichiro Otsuka1

  • 1Harvard Medical School and Massachusetts General Hospital, Boston, MA 02171, USA.

Biomedical Optics Express
|July 1, 2017
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) was adapted for intravascular imaging to diagnose atherosclerosis. This review details engineering, image interpretation, and clinical research from early studies to trials.

Keywords:
(170.3880) Medical and biological imaging(170.4500) Optical coherence tomography

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Imaging
  • Medical Device Development

Background:

  • Optical coherence tomography (OCT) initially imaged the eye's microstructure.
  • Intravascular imaging was developed for diagnosing and investigating atherosclerosis.
  • Monitoring therapeutic interventions for cardiovascular diseases is a key application.

Purpose of the Study:

  • To review the development of intravascular OCT systems.
  • To cover clinical applications, constraints, and engineering milestones.
  • To summarize image interpretation groundwork and clinical research.

Main Methods:

  • Review of historical development and engineering advancements in intravascular OCT.
  • Analysis of key studies for image interpretation.
  • Compilation of clinical research from pilot studies to trials.

Main Results:

  • Significant engineering milestones have led to high-performance commercial intravascular OCT systems.
  • Foundational studies established methods for interpreting intravascular OCT images.
  • Clinical research has progressed from initial human studies to ongoing clinical trials.

Conclusions:

  • Intravascular OCT has evolved significantly from its initial conception.
  • The technology is increasingly utilized for diagnosing and managing cardiovascular conditions.
  • Continued clinical research is vital for optimizing its therapeutic monitoring capabilities.