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Related Experiment Video

Updated: Feb 27, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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NIR-triggered high-efficient photodynamic and chemo-cascade therapy using caspase-3 responsive functionalized

Na Zhao1, Baoyan Wu1, Xianglong Hu1

  • 1MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.

Biomaterials
|July 1, 2017
PubMed
Summary
This summary is machine-generated.

Novel nanoparticles activate chemotherapy and photodynamic therapy upon near-infrared light exposure. This dual-action approach enhances tumor treatment by releasing drugs in response to caspase-3 activation, overcoming drug resistance.

Keywords:
Cascade chemotherapyCaspase-3NIRPhotodynamic therapyUpconversion nanoparticles

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Stimuli-responsive nanoparticles offer advanced tumor treatment capabilities.
  • Multifunctional nanoparticles are crucial for integrating diagnostics and therapeutics.

Purpose of the Study:

  • To develop novel caspase-3 responsive functionalized upconversion nanoparticles (CFUNs) for enhanced tumor treatment.
  • To achieve three-in-one functional integration: NIR-triggered photodynamic damage, caspase-3 responsive drug release, and cascade chemotherapeutic activation.

Main Methods:

  • Fabrication of CFUNs via self-assembly of DEVD-DOX prodrug, upconversion nanoparticles (UCNP), photosensitizer (MPPa), and tumor-targeting cRGD-PEG-DSPE.
  • Utilizing UCNP's NIR-triggered visible light emission to excite MPPa for reactive oxygen species (ROS) generation.
  • Leveraging caspase-3 activation to cleave DEVD peptide and release doxorubicin (DOX) for chemotherapy.

Main Results:

  • CFUNs demonstrated NIR-triggered photodynamic therapy (PDT) and cascade chemotherapy.
  • In vitro and in vivo experiments showed significant tumor inhibition due to consecutive PDT and chemotherapy.
  • CFUNs exhibited minimal toxicity in the dark, with potent therapeutic effects upon NIR irradiation.

Conclusions:

  • The developed CFUNs offer a promising platform for NIR-activated cascade tumor therapy.
  • This dual-mechanism approach is effective in overcoming multidrug resistance and tumor heterogeneity.
  • CFUNs hold potential for persistent and effective tumor treatment.