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Nine genetic polymorphisms associated with power athlete status - A Meta-Analysis
Jan Weyerstraß1, Kelly Stewart1, Anke Wesselius1
1Department of Complex Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre, The Netherlands.
Journal of Science and Medicine in Sport
|July 2, 2017
Summary
This meta-analysis identified nine genetic polymorphisms associated with power athlete status. These genetic variants may influence an individual's predisposition to becoming a power athlete.
Area of Science:
- Sports Science and Genetics
- Human Performance Genomics
Background:
- Understanding the genetic basis of athletic performance is crucial for identifying elite athletes.
- Power athlete status is influenced by a complex interplay of genetic and environmental factors.
Purpose of the Study:
- To investigate the association between specific genetic polymorphisms and power athlete status.
- To identify genetic variants that may confer a predisposition to power athletic performance.
- To explore potential interference by race and sex in these associations.
Main Methods:
- A comprehensive meta-analysis of case-control and cohort studies was conducted.
- Searched PubMed and Web of Science databases for relevant studies published between 2008 and 2016.
- Analyzed data from 5834 power athletes and 14,018 controls, calculating odds ratios for identified genetic variants.
- Performed stratified analyses by race and sex to assess heterogeneity.
Main Results:
- Significant associations were found for polymorphisms in the ACE, ACTN3, AGT, IL6, MnSOD, NOS3, and SOD2 genes.
- Specific genetic variants (e.g., rs1815739 in ACTN3) showed a notable link to power athlete status.
- Stratified analyses explored potential race and sex-specific effects on these genetic associations.
Conclusions:
- Nine genetic polymorphisms are significantly associated with power athlete status.
- These findings contribute to understanding the genetic underpinnings of power performance.
- Further research is warranted to fully elucidate the role of these genes in athletic development.
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