Related Experiment Video
Updated: Feb 27, 2026
06:21
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
2.2K
Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice
Wei-Sheng Lin1, Jung-Hsin Lo2, Jo-Hsuan Yang2
1Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Journal of Ethnopharmacology
|July 2, 2017
Summary
Ludwigia octovalvis extract (LOE) shows potent anti-diabetic effects by activating AMP-activated protein kinase (AMPK). This natural compound effectively lowers blood glucose and improves memory in diabetic models, suggesting clinical potential.
Area of Science:
- Pharmacology
- Metabolic Diseases
- Natural Products
Background:
- Ludwigia octovalvis (LO) extracts are traditionally used for various health conditions, including diabetes.
- Previous research demonstrated LOE's ability to extend lifespan and improve memory in Drosophila melanogaster by activating AMP-activated protein kinase (AMPK).
Purpose of the Study:
- To investigate the anti-hyperglycemic potential of Ludwigia octovalvis extract (LOE).
- To explore the role of AMP-activated protein kinase (AMPK) in mediating the anti-diabetic effects of LOE.
Main Methods:
- In vitro studies using C2C12 muscle and HepG2 liver cells to assess AMPK activation, glucose uptake, and glucose production.
- In vivo studies using streptozotocin (STZ)-induced and high-fat diet (HFD)-induced diabetic mouse models.
- Evaluation of cognitive function and motor activity in HFD-induced diabetic mice using behavioral tests.
Main Results:
- LOE and its component β-sitosterol significantly induced AMPK phosphorylation in muscle and liver cells.
- LOE enhanced glucose uptake and inhibited glucose production in vitro, effects dependent on AMPK activation.
- LOE demonstrated significant anti-hyperglycemic effects in diabetic mice, comparable to metformin.
- LOE improved glycemic control and cognitive function in HFD-induced diabetic mice.
Conclusions:
- Ludwigia octovalvis extract (LOE) is a potent AMPK activator with significant anti-diabetic properties.
- LOE demonstrates potential as a therapeutic intervention for managing hyperglycemia and related complications.
- Further clinical investigation of LOE for diabetes treatment is warranted.
