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Related Experiment Video

Updated: Feb 27, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Published on: July 1, 2014

Behavioral activation sensitivity and default mode network-subgenual cingulate cortex connectivity in youth.

Allesandra S Iadipaolo¹, Hilary A Marusak¹, Kelsey Sala-Hamrick²

¹Pharmacy Practice, Wayne State University, Detroit, MI, United States.

Behavioural Brain Research

|July 2, 2017

Summary

Higher behavioral activation system (BAS) sensitivity in at-risk youth is linked to reduced connectivity between the default mode network (DMN) and subgenual anterior cingulate cortex (sgACC). This suggests BAS sensitivity may protect against psychopathology by altering brain circuitry related to rumination.

Keywords:

Adolescents Children Early stress Resiliency Resting-state fMRI

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Published on: May 19, 2015

Area of Science:

Neuroscience
Developmental Psychology
Psychiatry

Background:

Increased resting-state functional connectivity (rsFC) between the default mode network (DMN) and subgenual anterior cingulate cortex (sgACC) is associated with affect dysregulation in youth.
Behavioral activation system (BAS) sensitivity may be a protective factor against psychopathology, particularly after stress or trauma exposure.

Purpose of the Study:

To investigate the association between BAS sensitivity and DMN-sgACC rsFC in high-risk youth.
To explore potential neurobiological mechanisms underlying resilience to psychopathology in at-risk youth.

Main Methods:

Resting-state functional magnetic resonance imaging (rsFC) was used to scan 98 children and adolescents (ages 6-17) at high sociodemographic risk.
A targeted, small-volume corrected approach was employed to analyze DMN-sgACC connectivity.
Behavioral activation system (BAS) sensitivity was assessed in the participants.

Main Results:

Youth with higher BAS sensitivity exhibited lower DMN-sgACC rsFC.
This finding suggests a link between BAS sensitivity and the stress-vulnerability circuitry involving the DMN and sgACC.
The results indicate that BAS sensitivity may modulate neural pathways implicated in rumination.

Conclusions:

Higher BAS sensitivity is associated with reduced DMN-sgACC connectivity in at-risk youth.
Interventions aimed at augmenting BAS sensitivity, such as behavioral activation therapy, may offer neurobiological protection against stress-related psychopathology.
These findings highlight the importance of bolstering resilience in at-risk urban youth through interventions targeting specific brain circuitry.