Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
Structure and Function of Platelets01:18

Structure and Function of Platelets

4.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted Protein Degradation Strategies in DNA Virus Research.

Viruses·2026
Same author

Are Suicide Prevention Interventions Effective for Current and Ex-Serving Military Personnel? A Systematic Review and Meta-Analysis Based on the Suicide Prevention Trials Database.

Suicide & life-threatening behavior·2026
Same author

Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Platelets: the next-generation ovarian cancer biomarker?

Trends in cancer·2026
Same author

Multimorbidity and suicidality among military veterans: a scoping review.

Psychiatry research·2026
Same author

The lived experience of clinical instructors as simulated patients: a qualitative study.

Journal of clinical education in physical therapy·2025

Related Experiment Video

Updated: Feb 27, 2026

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
07:32

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Published on: June 15, 2012

27.3K

Platelets, circulating tumor cells, and the circulome.

Preeti Kanikarla-Marie1, Michael Lam1, David G Menter1

  • 1Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Unit 426, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Cancer Metastasis Reviews
|July 2, 2017
PubMed
Summary

Platelets, small blood cells, play a dual role in health and cancer. This review explores their impact on the "Circulome," cancer progression, and potential therapeutic targets.

Keywords:
CTCCirculating tumor cellsCirculomeColorectal cancerLiquid biopsyTumor-educated plateletscfDNA

More Related Videos

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

9.2K
Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
05:49

Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle

Published on: April 27, 2021

3.0K

Related Experiment Videos

Last Updated: Feb 27, 2026

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
07:32

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Published on: June 15, 2012

27.3K
Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

9.2K
Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
05:49

Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle

Published on: April 27, 2021

3.0K

Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Platelets are anucleated cytoplasmic fragments derived from megakaryocytes.
  • They are key components of the "Circulome," encompassing circulating cells, factors, and macromolecules.
  • Platelets' primary role is hemostasis, but they also influence cancer development.

Purpose of the Study:

  • To review platelet contributions to the "Circulome."
  • To highlight the importance of platelets as diagnostic tools for cancer risk prediction.
  • To discuss therapies targeting platelet activation for cancer progression and metastasis inhibition.

Main Methods:

  • Literature review of platelet function in cancer.
  • Analysis of platelet interactions with tumor cells.
  • Examination of diagnostic and therapeutic applications of platelets in oncology.

Main Results:

  • Platelets interact with circulating tumor cells, promoting survival and metastasis.
  • Platelet activation, mediated by tumor cell crosstalk, enhances cancer progression.
  • Platelets serve as biomarkers for cancer risk and therapeutic targets.

Conclusions:

  • Platelets are integral to the "Circulome" and significantly impact cancer progression.
  • Targeting platelet activation offers a promising strategy for cancer therapy.
  • Platelet-based diagnostics and therapeutics hold potential in oncology.