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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome
Nobuhiro Yuki1,2, Amanda C Chan3, Anna Hiu Yi Wong1
1Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, 1E Kent Ridge Road, Singapore, 119228.
Introduction:
We present a painful small-fiber neuropathy variant of Guillain-Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation.
Methods:
Two patients received intravenous immunoglobulin, one corticosteroids.
Results:
The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses.
Discussion:
Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain-Barré syndrome. Muscle Nerve 57: 320-324, 2018.
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