Recent developments in biological activities of indanones
Siddappa A Patil1, Renukadevi Patil2, Shivaputra A Patil2
1Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore 562112, India.
European Journal of Medicinal Chemistry
|July 2, 2017
Summary
Indanone derivatives are versatile compounds with significant medicinal chemistry applications. This review highlights their diverse biological activities, including anticancer, antimicrobial, antiviral, and antialzheimer properties.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Pharmacology
Background:
- Indanone is a privileged structure found in natural products and synthetic molecules.
- It serves as a key intermediate for synthesizing medicinally important compounds.
- Donepezil, an acetylcholinesterase inhibitor for Alzheimer's disease, features the indanone core.
Purpose of the Study:
- To review recent biological applications of indanone derivatives.
- To explore their potential in treating various diseases.
Main Methods:
- Literature review of scientific articles on indanone derivatives.
- Analysis of biological activities reported for indanone compounds.
Main Results:
- Indanone derivatives exhibit a wide range of pharmacological activities.
- Notable activities include antialzheimer, anticancer, antimicrobial, and antiviral effects.
- Several indanone derivatives are in pre-clinical and clinical development.
Conclusions:
- Indanone derivatives represent a promising class of compounds for drug discovery.
- Their diverse therapeutic potential warrants further investigation for various medical conditions.
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